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What is Dyskinesia?

Brain with Molecule

It Starts with Dopamine

When you have Parkinson’s disease (PD), the brain stops producing enough dopamine. Dopamine is a chemical in your brain that works as a messenger—delivering signals to nerves in the body that coordinate movement, balance, and walking. That’s why if you have PD, you may not be able to move the way you want to.

Trophy Cup

Levodopa: The Gold Standard

Treatment with levodopa is the current standard of care, but as PD advances, higher doses of levodopa are needed. Disease progression and long-term use of levodopa at higher doses can lead to dyskinesia. Dyskinesia makes it harder to get the most from any levodopa-based treatment plan.

You may notice dyskinesia as:

Areas of the body where dyskinesia may have an impact Areas of the body where dyskinesia may have an impact

It’s important to understand that dyskinesia and tremors are not the same

Tremors* Dyskinesia
What is it? Uncontrollable back and forth shaking movement that mainly affects the arms or legs when at rest and stops for the duration of a voluntary movement. Tremors are a common symptom of PD Sudden, uncontrolled, jerky movements caused by PD progression and long-term use of levodopa at higher doses. Dyskinesia can be very noticeable
Where will I feel it on my body? Tremors are usually felt in the hand or foot and appear when a person's muscles are relaxed or at rest. Tremors may start on one side of the body but can include the entire body Dyskinesia can affect the neck/face, arms, legs, torso, or entire body
What does it look like? During a tremor, the affected body part trembles or shakes when performing actions like resting or walking Dyskinesia can also look like fidgeting, head bobbing, writhing or wriggling, or like the entire body is rocking back and forth
What is it?
Tremors* Dyskinesia
Uncontrollable back and forth shaking movement that mainly affects the arms or legs when at rest and stops for the duration of a voluntary movement. Tremors are a common symptom of PD Sudden, uncontrolled, jerky movements caused by PD progression and long-term use of levodopa at higher doses. Dyskinesia can be very noticeable
Where will I feel it on my body?
Tremors* Dyskinesia
Tremors are usually felt in the hand or foot and appear when a person's muscles are relaxed or at rest. Tremors may start on one side of the body but can include the entire body Dyskinesia can affect the neck/face, arms, legs, torso, or entire body
What does it look like?
Tremors* Dyskinesia
During a tremor, the affected body part trembles or shakes when performing actions like resting or walking Dyskinesia can also look like fidgeting, head bobbing, writhing or wriggling, or like the entire body is rocking back and forth
*
GOCOVRI is not an approved treatment for tremors.

Dyskinesia is common in PD

Dyskinesia impacts many people with Parkinson’s disease Dyskinesia impacts many people with Parkinson’s disease

Only your doctor can properly diagnose if you have dyskinesia

Talk to your doctor or healthcare provider if you think you might have dyskinesia

The reality of dyskinesia

This is what dyskinesia may feel like

Lighting cloud

Many people with PD have said they experience a mix of feelings and emotions because of dyskinesia, which can affect day-to-day activities. Even before dyskinesia hits, there's often a feeling. Some people with PD describe it as the same feeling you get right before a storm.

Suddenly, you may feel your hand pull away. A twitch, a jerk—and you may think, "not now." You may sit on your hand. Or hold down your leg. Or shift your body. Or try laughing it off. Many people with PD describe doing whatever they can to get through it.

These moments of dyskinesia may lead to spills, drops, and breaks. At the wrong time, those moments become interruptions at work, home, or when you’re out socially. Managing all of this can be frustrating and get in the way of your best laid plans.

Dyskinesia may even have you and your doctor rethinking your PD treatment plan.

This is what dyskinesia may feel like

Many people with PD have said they experience a mix of feelings and emotions because of dyskinesia, which can affect day-to-day activities. Even before dyskinesia hits, there's often a feeling. Some people with PD describe it as the same feeling you get right before a storm.

Suddenly, you may feel your hand pull away. A twitch, a jerk—and you may think, "not now." You may sit on your hand. Or hold down your leg. Or shift your body. Or try laughing it off. Many people with PD describe doing whatever they can to get through it.

These moments of dyskinesia may lead to spills, drops, and breaks. At the wrong time, those moments become interruptions at work, home, or when you’re out socially. Managing all of this can be frustrating and get in the way of your best laid plans.

Dyskinesia may even have you and your doctor rethinking your PD treatment plan.


Watch Ervin, a person with PD, describe how dyskinesia impacts him

It's important to track your symptoms to see how dyskinesia is affecting you

Download The
Symptom Tracker

Dyskinesia is troublesome if it's troublesome to you

What could reducing dyskinesia mean to you?

For some, dyskinesia may interfere with their work. For others it takes time away from their social life. If dyskinesia is troublesome or bothersome in any way that interferes with these moments in your day-to-day life, then you and your doctor should talk about it.

Ways dyskinesia can affect people with Parkinson's disease Ways dyskinesia can affect people with Parkinson's disease

Set New Goals

Take some time to think about the goals you would want to achieve with less dyskinesia. Write them down and discuss them with your doctor

Finding a Different Way

Good movement control isn't easy with dyskinesia

Balance scale

Making Trade-Offs

Good movement control can become a balancing act that means choosing between treating PD symptoms and reducing dyskinesia. This may lead to more time spent not realizing the full benefit of your PD medications or tinkering with them. You may also spend time making adjustments to daily activities.

Brain and gradient molecules

GOCOVRI Helps Make It Possible

GOCOVRI isn’t a dopamine-based medicine. GOCOVRI is believed to work through a different receptor in the brain that is equally important in PD, known as glutamate. GOCOVRI doesn’t interfere with levodopa.

In clinical studies, GOCOVRI was proven to help people with PD experience

Less Dyskinesia, as well as reduced "OFF" time

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Important Safety Information

Before taking GOCOVRI, tell your doctor about all medical conditions, including if you:

  • have kidney problems; unexpected sleepiness; take medicine to help you sleep or that makes you drowsy; have mental problems, such as suicidal thoughts, depression, or hallucinations; unusual urges including gambling, increased sex drive, compulsive eating, or shopping; or if you drink alcoholic beverages
  • are pregnant or plan to become pregnant or are breastfeeding or plan to breastfeed. GOCOVRI may harm your unborn baby and can pass into your breastmilk

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take medicines like sodium bicarbonate.

What should I avoid while taking GOCOVRI?

  • Do not take GOCOVRI if you have severe kidney problems
  • Do not drive, operate machinery, or do other dangerous activities until you know how GOCOVRI affects you
  • Do not drink alcohol while taking GOCOVRI as it can increase your chances of serious side effects
  • Do not stop or change the dose of GOCOVRI before talking with your doctor. Call your healthcare provider if you have symptoms of withdrawal such as fever, confusion, or severe muscle stiffness
  • Do not take a flu nasal spray while taking GOCOVRI, but you can receive a flu shot

What are the possible side effects of GOCOVRI?

GOCOVRI may cause serious side effects, including:

  • falling asleep during normal activities, such as driving, talking, or eating, while taking GOCOVRI. You may fall asleep without being drowsy or warning. The risk is greater if you take GOCOVRI with medicines that cause drowsiness
  • suicidal thoughts or actions and depression
  • occurrence or worsening of hallucinations (seeing or hearing things that are not real)
  • feeling dizzy, faint or light headed, especially when you stand up too quickly, when first starting GOCOVRI, or if your dose has been increased
  • unusual urges including gambling, sexual, spending money, binge eating, and the inability to control them

If you or your family notices that you are developing any new, unusual or sudden changes in behavior or related symptoms, tell your healthcare provider right away.

The most common side effects of GOCOVRI include hallucination, dizziness, dry mouth, swelling of legs and feet, constipation, and falls.

Be sure to take your medicine at bedtime as instructed. You may take GOCOVRI with or without food.

Indication

What is GOCOVRI?

GOCOVRI™ (amantadine) extended release capsules is a prescription medicine for treating dyskinesia (sudden uncontrolled movements) in Parkinson’s disease patients treated with levodopa therapy, with or without other medicines that increase the effects of dopamine in the brain. It is not known if GOCOVRI is safe and effective in children.