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A new way to look at defining movement control

Terms to know

Dyskinesia Uncontrolled, jerky movements. Feels and looks like fidgeting, head bobbing, or like the body is rocking back and forth. It can affect the arms, legs, or torso and can occur in one part of your body or throughout. Dyskinesia can occur during periods of "ON" time
"ON" Time Your Parkinson's disease (PD) medicines are working. You are moving but not always with good control
"OFF" Time Your PD medicines are not working well or at all. PD symptoms—feeling like you're walking through mud (rigid), involuntary shaking (tremors), or being completely frozen—are in full effect
Functional Time "ON" time without troublesome dyskinesia. This is time when your PD symptoms are well controlled and you're not experiencing dyskinesia
Dyskinesia
Uncontrolled, jerky movements. Feels and looks like fidgeting, head bobbing, or like the body is rocking back and forth. It can affect the arms, legs, or torso and can occur in one part of your body or throughout. Dyskinesia can occur during periods of “ON” time
"ON" Time
Your Parkinson's disease (PD) medicines are working. You are moving but not always with good control
"OFF" Time
Your PD medicines are not working well or at all. PD symptoms—feeling like you’re walking through mud (rigid), involuntary shaking (tremors), or being completely frozen—are in full effect
Functional Time
"ON" time without troublesome dyskinesia. This is time when your PD symptoms are well controlled and you're not experiencing dyskinesia

Set new treatment goals around dyskinesia and functional time

GOCOVRI puts more movement back in your control

People with PD had less dyskinesia and more functional time

GOCOVRI was evaluated in 2 clinical studies* of nearly 200 people with PD who had dyskinesia. In 1 study, people taking GOCOVRI over 12 weeks experienced:

GOCOVRI clinical study results GOCOVRI clinical study results
*
In both studies, the primary goal was to measure dyskinesia using the Unified Dyskinesia Rating Scale (UDysRS); the key secondary goal was "ON" time without troublesome dyskinesia using PD home diaries.
People treated with GOCOVRI saw an improvement in functional time by 3.6 hours in Study 1 and 4.0 hours in Study 2.
This result was based on placebo-adjusted data which is the difference between people who took GOCOVRI and those who took placebo.

Watch Ervin share his experience with GOCOVRI


The Unified Dyskinesia Rating Scale

GOCOVRI used a scale designed specifically to better understand dyskinesia

In clinical studies, dyskinesia was measured using the Unified Dyskinesia Rating Scale (UDysRS)—the first validated tool of its kind. The UDysRS assesses the impact of dyskinesia on important and relatable activities of daily living including:

Effects of dyskinesia on activities of daily living Effects of dyskinesia on activities of daily living

WHAT WOULD YOU DO WITH LESS DYSKINESIA AND MORE FUNCTIONAL TIME?

Start the conversation with your doctor

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Important Safety Information

Before taking GOCOVRI, tell your doctor about all medical conditions, including if you:

  • have kidney problems; unexpected sleepiness; take medicine to help you sleep or that makes you drowsy; have mental problems, such as suicidal thoughts, depression, or hallucinations; unusual urges including gambling, increased sex drive, compulsive eating, or shopping; or if you drink alcoholic beverages
  • are pregnant or plan to become pregnant or are breastfeeding or plan to breastfeed. GOCOVRI may harm your unborn baby and can pass into your breastmilk

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take medicines like sodium bicarbonate.

What should I avoid while taking GOCOVRI?

  • Do not take GOCOVRI if you have severe kidney problems
  • Do not drive, operate machinery, or do other dangerous activities until you know how GOCOVRI affects you
  • Do not drink alcohol while taking GOCOVRI as it can increase your chances of serious side effects
  • Do not stop or change the dose of GOCOVRI before talking with your doctor. Call your healthcare provider if you have symptoms of withdrawal such as fever, confusion, or severe muscle stiffness
  • Do not take a flu nasal spray vaccine while taking GOCOVRI, but you can receive a flu shot

What are the possible side effects of GOCOVRI?

GOCOVRI may cause serious side effects, including:

  • falling asleep during normal activities, such as driving, talking, or eating, while taking GOCOVRI. You may fall asleep without being drowsy or warning. The risk is greater if you take GOCOVRI with medicines that cause drowsiness
  • suicidal thoughts or actions and depression
  • occurrence or worsening of hallucinations (seeing or hearing things that are not real)
  • feeling dizzy, faint or light headed, especially when you stand up too quickly, when first starting GOCOVRI, or if your dose has been increased
  • unusual urges including gambling, sexual, spending money, binge eating, and the inability to control them

If you or your family notices that you are developing any new, unusual or sudden changes in behavior or related symptoms, tell your healthcare provider right away.

The most common side effects of GOCOVRI include hallucination, dizziness, dry mouth, swelling of legs and feet, constipation, and falls.

Be sure to take your medicine at bedtime as instructed. You may take GOCOVRI with or without food.

Indication

What is GOCOVRI?

GOCOVRI™ (amantadine) extended release capsules is a prescription medicine for treating dyskinesia (sudden uncontrolled movements) in Parkinson’s disease patients treated with levodopa therapy, with or without other medicines that increase the effects of dopamine in the brain. It is not known if GOCOVRI is safe and effective in children.